PUBLIKATIONSLISTA

Originalartiklar

Wennberg C, Lundborg M, Lindahl E, Norlén L (2023) Understanding Drug Skin Permeation Enhancers Using Molecular Dynamics Simulations. J. Chem. Inf. Model. 2023 Aug 14;63(15):4900-4911

Norlén L (2023) Molecular Organization of the Skin Barrier. Acta Derm Venereol. 2023 Nov 21:103:adv13356. doi:10.2340/actadv.v103.13356

Lundborg, M. Wennberg,C. Lidmar, J. Hess, B. Lindahl, E. Norlen, L (2022) Skin permeability prediction with MD simulation sampling spatial and alchemical reaction coordinates, Biophysical Journal, https://doi.org/10.1016/j.bpj.2022.09.009

Norlén, L. Lundborg, M. Wennberg, C. Narangifard, A. Daneholt, B (2022) The Skin’s Barrier: A Cryo-EM Based Overview of its Architecture and Stepwise Formation. J. Invest. Dermatol. 142:285-292

Narangifard, A. Wennberg, CL. den Hollander, L. Iwai, I. Han, H. Lundborg, M. et al. (2021) Molecular reorganization during formation of the human skin barrier studied in situ. J. Invest. Dermatol. 141(5):1243-1253.e6.

Lundborg, M. Wennberg, C. Narangifard, A. Lindahl, E. Norlén, L (2018b) Predicting Drug Permeability Through Skin Using Molecular Dynamics Simulation. J. Controlled Release 283:269-279

Lundborg, M. Narangifard, A. Wennberg, C. Lindahl, E. Norlén, L (2018a) Human Skin Barrier Molecular Structure and Function Analyzed by Cryo-Electron Microscopy and Molecular Dynamics Simulation. J. Struct. Biol. 203(2):149-161

Wennberg, C. Narangifard, A. Lundborg, M. Lindahl, E. Norlén, L (2018) Structural transitions in ceramide cubic phases during formation of the human skin barrier. Biophys. J. 114(5):1116-1127

Narangifard, A. den Hollander, L. Iwai, I. Han, H. Wennberg, CL. Lundborg, M. Lindahl, E. Masich, S. Daneholt, B. and Norlén, L (2018) Human skin barrier formation takes place via a cubic to lamellar lipid phase transition. Exp. Cell Res. 366(2):139-151

den Hollander, L. Han, H-M. de Winter, M. Svensson, L. Masich, S. Daneholt, B. Norlén, L (2016) Skin lamellar bodies are not discrete vesicles but part of a tubuloreticular network. ACTA Dermato-Venereol. 96(3):303-308

Norlén, L (2014) Update of technologies for examining stratum corneum. Br J. Dermatol. 171:13-18

Norlén, L (2013) Current understanding of skin barrier morphology. Skin Pharm. Phys. 26:213-216

Iwai, I. Han, H. den Hollander, L. Svensson, S. Öfverstedt, L-G. Anwar, J. Brewer, J. Bloksgaard Mølgaard, M. Laloeuf, A. Nosek, D. Masich, S. Bagatolli, L. Skoglund, U. Norlén, L (2012) The human skin barrier is organized as stacked bilayers of fully-extended ceramides with cholesterol molecules associated with the ceramide sphingoid moiety. J. Invest. Dermatol. 132:2215–2225

Johnsen, GK. Norlén, L. Martinsen, Ö. Grimnes, S (2011) Sorption properties of the human stratum corneum. Skin Pharmacol. Physiol. 24:190-198

Norlén, L. Öktem, O, Skoglund, U (2009) Molecular cryo-electron tomography of vitreous tissue sections: current challenges. J. Microscopy 235:293-307

Plasencia, I. Norlén, L. Bagatolli, LA (2007). Direct visualization of lipid domains in human skin stratum corneum’s lipid membranes: effect of pH and temperature. Biophysical J. 93:3142-3155

Norlén, L. Plasencia, I. Simonsen, A. Descouts, P (2007) Human stratum corneum lipid organization as observed by atomic force microscopy on Langmuir-Blodgett films. J. Struct. Biol. 158:386-400

Norlén, L. Masich, S. Goldie, KN. Hoenger, A (2007) Structural analysis of vimentin and keratin intermediate filaments by cryo-electron tomography. Exp. Cell Res. 313:2217-2227

Masich, S. Östberg, T. Norlén, L. Shupliakov, O. and Daneholt, B (2006) A procedure to deposit fiducial markers on vitreous cryo-sections for cellular tomography. J. Struct. Biol. 156:461-468

Al-Amoudi, A. Dubochet, J. Norlén, L (2005) Nanostructure of the epidermal extracellular space as observed by cryo-electron microscopy of vitreous sections of human skin. J. Invest. Dermatol. 124:764-777

Norlén, L. Al-Amoudi, A (2004) Stratum corneum keratin structure, function, and formation: the cubic rod-packing and membrane templating model. J Invest Dermatol. 123(4):715-32

Al-Amoudi, A. Norlén, L. Dubochet, J (2004) Cryo-electron microscopy of vitreous sections of native biological cells and tissues. J Struct Biol. 148(1):131-5

Al-Amoudi, A. Chang, J-J. Leforestier, A. McDowall, A. Michel Salamin, L. Norlén, L. Richter, K. Sartori Blanc, N. Studer, D. Dubochet, J (2004) Cryo-electron microscopy of vitreous sections. EMBO J. 15;23(18):3583-8

Westerberg, R. Tvrdik, P. Undén, A-B. Månsson, J-E. Norlén, L. Jakobsson, A. Holleran, W. Elias, P.M., Asadi, A. Flodby, P. Toftgård, R. Capecchi, M. Jacobsson, A (2004) Role of ELOVL3 and fatty acid chain length in development of hair and skin function. J. Biol. Chem. 279:5621-5629

Norlén, L. Al-Amoudi, A. Dubochet, J (2003) A cryo-transmission electron microscopy study of skin barrier formation. J. Invest. Dermatol. 120:555-560

Norlén, L (2003) Skin barrier structure, function and formation – learning from cryo-electron microscopy of vitreous, fully hydrated native human epidermis. Int. J. Cosm. Sci. 25:1-18

Norlén, L (2003) Molecular skin barrier models and some central problems for the understanding of skin barrier structure and function. Skin Pharm. Appl. Physiol. 16(4):203-211

Norlén, L (2002) Does the single gel-phase exist in stratum corneum? J. Invest. Dermatol. 118(5):899-901

Norlén, L (2001) Skin barrier formation: the membrane folding model. J. Invest. Dermatol. 117(4):823-829

Norlén, L (2001) Skin barrier structure and function: the single gel-phase model. J. Invest. Dermatol. 117(4):830-836

Norlén, L. Engblom, J (2000) Structure-related aspects on water diffusivity in fatty acid-soap and skin lipid model systems. J. Control. Release 63(1-2):213-226

Norlén, L. Engblom, J. Anderson, M. Forslind, B (1999) A new computer-based evaporimeter system for rapid measuerments of water diffusion through stratum corneum in-vitro. J. Invest. Dermatol. 113(4):533-540

Norlén, L. Nicander, I. Lundh-Rozell, B. Ollmar, S. Forslind, B. (1999) Inter and intra individual differences in human stratum corneum lipid content related to physical parameters of skin barrier function. J. Invest. Dermatol. 112(1):72-77

Norlén, L. Nicander, I. Lundsjö, A. Cronholm, T. Forslind, B. (1998) A new HPLC-based method for the quantitative analysis of inner stratum corneum lipids with special reference to the free fatty acid fraction. Arch. Derm. Res. 290:508-516

Nicander, I. Norlén, L. Brockstedt, U. Lundh-Rozell, B. Forslind, B. Ollmar, S. (1998) Electrical impedance and other physical parameters as related to lipid content of human stratum corneum. Skin research and technology 4:213-221

Forslind, B. Norlén, L. Engblom J (1998) A structural model for the human skin barrier. In Colloid Science of Lipids. New Paradigms for self-assembly in Science and Technology. Progr. Colloid and Polym. Sci. 108:40-46

Nicander, I. Norlén, L. Forslind, B. Ollmar S (1998) Lipid content and electrical impedance. Curr Probl Dermatol. 26:165-76

Norlén, L. Emilson, A. Forslind, B. (1997) Stratum corneum swelling. Biophysical and computer assisted quantitative assessments. Arch. Derm. Res. 289(9): 506-513

Forslind, B. Engström, S. Engblom, J. Norlén, L. (1997) A novel approach to the understanding of human skin function. J. Dermatological Science (Japan) 14:115-125